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Wednesday, July 29, 2020 | History

2 edition of The endolymphatic duct and sac in the guinea pig found in the catalog.

The endolymphatic duct and sac in the guinea pig

Per-G Lundquist

The endolymphatic duct and sac in the guinea pig

an electron microscopic and experimental investigation

by Per-G Lundquist

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  • 3 Currently reading

Published by [Norstedt] in Stockholm .
Written in English

    Subjects:
  • Labyrinth (Ear)

  • Edition Notes

    Statementby Per-Gotthard Lundquist
    SeriesActa oto-laryngologica. Supplementum -- 201, Acta oto-laryngologica -- 201
    The Physical Object
    Pagination108 p.
    Number of Pages108
    ID Numbers
    Open LibraryOL22790566M

    Guinea pigs placed outside or inside a pressure chamber and exposed to cm H2O overpressure continuously for 24 h immediately after blockage of the endolymphatic duct showed no significant difference in the magnitude of endolymphatic hydrops when compared to controls, although there was a slight indication of a volume decrease in the outside-tr.   Kimura RS. Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig. A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol. ; – [Google Scholar].

    Kimura, RS: Experimental blockage of the endolymphatic duct and sac and its effects on the inner ear of the guinea pig: A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol – , Another experimental model is the acute endolymphatic hydrops, which involves the injection of artificial endolymph into scala media of the guinea pig's cochlea (Valk et al., , ).

    Lundquist P-G. Aspects on endolymphatic sac morphology and function. Arch Otorhinolaryngol. ; – doi: /BF [Google Scholar] Lundquist PG, Kimura R, Wersäll J. Ultrastructural organization of the epithelial lining in the endolymphatic duct and sac in the guinea pig. Acta Otolaryngol. Therefore, experimentally models of endolymphatic hydrops, which created by surgical ablation of the endolymphatic duct and sac in guinea pigs, were widely used to investigate the pathological changes of MD associated with ELH [30,31].


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The endolymphatic duct and sac in the guinea pig by Per-G Lundquist Download PDF EPUB FB2

LII Experimental Blockage of the Endolymphatic DUCT and SAC and ITS Effect on the Inner Ear of the Guinea Pig Robert S. Kimura Annals of Otology, Rhinology & Laryngology 3, Cited by:   Lundquist PG: The endolymphatic duct and sac in the guinea pig: An electron microscopic and experimental investigation.

Acta Otolaryngol ; Kimura RS, Schuknecht HF: Membranous hydrops in the inner ear of the guinea pig after obliteration of the endolymphatic sac. Cited by: Lundquist PG () The endolymphatic duct and sac in the guinea pig: an electron microscopic and experimental investigation.

Acta Otolaryng (Stockh) [Suppl] Google Scholar McDonald DM () Neurogenic inflammation in the rat by: Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig.

A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol –, Cited by: The endolymphatic sac lies in the bony niche of the posterior surface of the pyramid. It partly touches the dura mater of the posterior fossa.

The endolymphatic sac communicates with the endolymphatic system through the endolymphatic duct. The epithelia of the sac Author: Yasuo Harada. The endolymphatic sac and cochlear aqueduct are primary passages of the endolymphatic and perilymphatic fluid compartments in the labyrinth.

Closure of the endolymphatic sac and duct in the guinea pig will result in the development of endolymphatic hydrops. (9) To date, the most reliable animal model of hydrops has been the guinea pig, the model initially described by Kimura and Schuknecht.

(10) However, studies of endolymphatic duct obstruction in primates have not as strongly supported its role as a principal inciting pathologic entity in Meniere's disease in humans. The Flow of Endolymph—A Unified Concept.

Author links open overlay panel Merle Lawrence Ph.D. Show more. The endolymphatic duct in the mammalian embryo is described conventionally as ending in a simple dilated extremity, the endolymphatic sac; and so far as the Writer knows, it is not stated in any textbook that from the distal aspect of the endolymphatic sac in young human embryos there regularly extends a considerable projection the length of.

A third and final article will discuss the practical therapeutic implications that stem from the concept that "idiopathic" hydrops of endolymph, the disease so clearly described by Prosper Meniere inis most often the result of deficient resorption by the endolymphatic duct and sac.

In conclusion, the presented method is a modified occipital, extradural approach that involves obliterating the endolymphatic sac and injuring the endolymphatic duct with a fine pick to induce experimental endolymphatic hydrops at 30 days post-operatively in the guinea pig.

In 36 guinea pigs the endolymphatic ducts were opened in normal ears as well as in ears in which hydrops had been induced by obliteration of the endolymphatic duct and sac. When the normal endolymphatic duct was opened and disconnected from the sac, either hydrops did not develop or mild hydrops developed after short survival times.

However, when the blocked duct of the hydropic inner. Histological EH has been induced in guinea pigs by chronic administration of VP through subcutaneous mini-osmotic pumps. 6 Alternatively, malabsorption of endolymph by the endolymphatic sac can result in EH.

Surgical obstruction of the endolymphatic duct and sac is a well-established model of EH in guinea pigs.9, 10, 11, Lundquist PG: The endolymphatic duct and sac in the guinea pig: An electron microscopic and experimental investigation.

Acta Otolaryngol,(suppl ), pp Antunez JCM, Galey FR, Linthicum FH, et al: Computer-aided and graphic reconstruction of the human endolymphatic duct and sac.

Ann Otol Rhinol. Request PDF | Quantitative anatomy of the guinea pig endolymphatic sac | The endolymphatic sac is believed to represent one of the primary loci for endolymph volume regulation in the inner ear.

The classical guinea pig model for Meniere's disease, in which endolymphatic hydrops was achieved by destruction of the endolymphatic sac and obliteration of the endolymphatic duct, is a non. Kimura R. Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig.

Annals of Otology, Rhinology, and Laryngology. ; – From the posterior wall of the saccule a canal, the endolymphatic duct, is given off; this duct is joined by the ductus utriculosaccularis, and then passes along the aquaeductus vestibuli and ends in a blind pouch (endolymphatic sac) on the posterior surface of the petrous portion of the temporal bone, where it is in contact with the dura mater.

Surgical induction of endolymphatic hydrops (ELH) in the guinea pig by obliteration and obstruction of the endolymphatic duct is a well-accepted animal model of the condition and an important correlate for human Meniere's disease.

InRobert Kimura. Endolymphatic hydrops, or dilation of the endolymphatic space, was first described independently in by Yamakawa and Hallpike and Cairns as the foremost pathologic correlate to Meniere's had described the movement of endolymph toward the endolymphatic sac, noting that endolymph is formed by the stria vascularis, flows into the sacculus and through to the endolymphatic duct.

the endolymphatic sac (es), which is a part of the inner ear, is believed to absorb endolymph, since surgical blockage of the ES and the endolymphatic duct causes accumulation of endolymph in the cochlea and vestibule, as so-called endolymphatic hydrops (), a characteristic pathological finding in Meniere's mphatic hydrops in the cochlea causes deafness, while endolymphatic.ENDOLYMPHATIC DUCT AND SAC IN GUINEA-PIG 3 the distal part of the sac again had a squamous epithelium.

This description applied directly to the cat, and he stated that the epithelium in the human newborn was ‘flacher’ than that of the cat. That very little attention has been paid to Boettcher’s ob.Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig.

Ann Otol Rhinol Laryngol. ; 2. Arenberg IK, Murray JP, Rauchbach E, Schenck NL. An experimental model for the study of endolymphatic hydrops in sharks: implications for the clinician.